Rat
Pathology Services Compliant with NMPA and FDA
Necropsy & Gross Observation
Histology & Staining
Histopathology Evaluation
Whole Slide Scanning & Histomorphometry
ICH
Mouse
Guinea Pig
Rabbit
Dog
Monkey
Pig
Sheep
Our Professional Pathology Services
Pathology Studies
Implantation Studies: Bone, Muscle, Subcutaneous Toxicity Studies: Acute, Subchronic, Chronic Irritation Studies: Rectum, Vagina and Penis Surgical Studies: Orthopedic Model, Cartilage Defect model, Cardiovascular model, etcMedical Device Products
Bone and Cartilage: Bone Plate, Spinal Fixation System,Screws, Bone Cement, 3D Printed Implant, etc. Cardiovascular: Embolization Microspheres, Fluid Embolization System, Guidance Catheter, Balloon Catheter, Coronary Stent, Thrombosis Catcher, etc. Skin And Soft Tissue: Anastomotic Nails, Sutures, etc. Nervous System: Cortical Electrodes, etc. Others: Bronchial AblationPathologists
Veterinary Pathologists accredited by the American College of Veterinary Pathology (DACVP)
ACVP Consultants Team providing expert veterinary pathology support
Veterinary Pathologists accredited by the Chinese College of Veterinary Pathology (DCCVP)
Toxicologists accredited by the Chinese Society of Toxicology (DCST)
Necropsy & Gross Observation
Euthanasia Procedures: Small and large animals (Rat, Mouse, Dog, Monkey, Rabbit, Guinea Pig, Mini Pig, Sheep)
Blood Collection at Termination
Full Panel Tissue Collection
Special Tissue Collection: Frozen Tissue, RNA, IHC
Tissue Fixation: 10% Formalin, Modified Davidson’s, Perfusion Fixation, Other Fixatives
Data Collection: Organ Weight Data, Gross Observation Data
Euthanasia Procedures: Small and large animals (Rat, Mouse, Dog, Monkey, Rabbit, Guinea Pig, Mini Pig, Sheep)
Blood Collection at Termination
Full Panel Tissue Collection
Special Tissue Collection: Frozen Tissue, RNA, IHC
Tissue Fixation: 10% Formalin, Modified Davidson’s, Perfusion Fixation, Other Fixatives
Data Collection: Organ Weight Data, Gross Observation Data
Histology Services & Workflow
Hard Tissue Processing Workflow
Histology Embedding Methods
Embedding by Resin-For Hard Tissue Section
Embedding by Paraffin-For Paraffin Section
Paraffin Section – H&E Staining
Lung
Kidney
Cerebellum
Hard Tissue Sections
HE Staining
Bone - Metal Implant
Coronary Stent
Special Staining
Bone - Von Kossa
Bone - Goldner’s Trichome
Histopathology Evaluation
Key Observation Points in Histopathology
Interface between device and tissues (Local effect around implant, inflammation, fibrosis, necrosis, infection, etc.)
Adjacent Tissue Damage (Degeneration/Necrosis, vasculitis, etc.)
Other Findings (Infarction, congestion, thrombi, etc.)
Select the Applicable Scoring System
Routine Tissue Evaluation Term: INHAND
Local Effect around Implant: ISO 10993-6&GB/T16886.6
Special Scoring System: e.g. Scoring system to blood vessels, Cartilage Defect -Modified O’Driscoll Scoring System
Photography for Representative Findings
Histomorphometry
Equipment
Olympus CellSense
NIKON NIS-Elements D
BIOQUANT OSTEO Scanning Microscope and Image Analysis System (Whole Slide Scanning and Analysis for both Paraffin and Hard sections)
Measurement Parameters
Length
Area
New Bone Formation
Bone-Implant Contact, BIC
Materials Degradation
Cell Numbering
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