Rat
Pathology Services Compliant with NMPA and FDA
Necropsy & Gross Observation
Histology & Staining
Histopathology Evaluation
Whole Slide Scanning & Histomorphometry
ICH
Mouse
Guinea Pig
Rabbit
Dog
Monkey
Pig
Sheep
Pathology Service Studies & Product Types
Studies
Implantation Studies: Bone, Muscle, Subcutaneous Toxicity Studies: Acute, Subchronic, Chronic Irritation Studies: Rectum, Vagina and Penis Surgical Studies: Orthopedic Model, Cartilage Defect model, Cardiovascular model, etcProducts
Bone and Cartilage: Bone Plate, Spinal Fixation System,Screws, Bone Cement, 3D Printed Implant, etc. Cardiovascular: Embolization Microspheres, Fluid Embolization System, Guidance Catheter, Balloon Catheter, Coronary Stent, Thrombosis Catcher, etc. Skin And Soft Tissue: Anastomotic Nails, Sutures, etc. Nervous System: Cortical Electrodes, etc. Others: Bronchial AblationPathologists
5
Veterinary Pathologist accredited by the American College of Veterinary Pathology（DACVP） 3
US St. Paul Senior Medical Device Pathologists（DACVP） 11
Veterinary Pathologist accredited by the Chinese College of Veterinary Pathology（DCCVP） 11
Study PathologistsNecropsy & Gross Observation
Euthanasia: Small animals and Large Animals (Rat, Mouse, Dog, Monkey, Rabbit, Guinea Pig, Mini Pig, Sheep)
Blood collection at Termination
Full Panel of Tissue Collection
Special Tissue : Frozen Tissue, RNA, IHC
Tissue Fixation：10%Formalin，Modified Davidson’s, Perfusion Fixation, Other Fixation
Data Collection: Organ Weight Data, Gross Data
Euthanasia: Small animals and Large Animals (Rat, Mouse, Dog, Monkey, Rabbit, Guinea Pig, Mini Pig, Sheep)
Blood collection at Termination
Full Panel of Tissue Collection
Special Tissue : Frozen Tissue, RNA, IHC
Tissue Fixation：10%Formalin，Modified Davidson’s, Perfusion Fixation, Other Fixation
Data Collection: Organ Weight Data, Gross Data
Histology
Hard Tissue
Histology
Embedding by Resin-For Hard Tissue Section
Embedding by Paraffin-For Paraffin Section
Paraffin Section - HE Staining
Lung
Kidney
Cerebellum
Hard Tissue Section
HE Staining
Bone - Metal Implant
Coronary Stent
Special Staining
Bone - Von Kossa
Bone - Goldner’s Trichome
Histopathology Evaluation
Key Observation Points in Histopathology
Interface between device and tissues (Local effect around implant, inflammation, fibrosis, necrosis, infection, etc.)
Adjacent Tissue Damage (Degeneration/Necrosis, vasculitis, etc.)
Other Findings (Infarction, congestion, thrombi, etc.)
Select the Applicable Scoring System
Routine Tissue Evaluation Term: INHAND
Local Effect around Implant: ISO 10993-6&GB/T16886.6
Special Scoring System: e.g. Scoring system to blood vessels, Cartilage Defect -Modified O’Driscoll Scoring System
Photography for Representative Findings
Histomorphometry
Equipment
Olympus CellSense
NIKON NIS-Elements D
BIOQUANT OSTEO Scanning Microscope and Image Analysis System (Whole Slide Scanning and Analysis for both Paraffin and Hard sections)
Measurement Parameters
Length
Area
New Bone Formation
Bone-Implant Contact, BIC
Materials Degradation
Cell Numbering
……